Rapid-Antigen Detection Tests for Group A Streptococcal Pharyngitis: Revisiting False-Positive Results Using Polymerase Chain Reaction Testing
2013
Cohen, Jérémie F. | Cohen, Robert | Bidet, Philippe | Levy, Corinne | Deberdt, Patrice | d'Humières, Camille | Liguori, Sandrine | Corrard, François | Thollot, Franck | Mariani-Kurkdjian, Patricia | Chalumeau, Martin | Bingen, Edouard
We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.
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