Rapid-Antigen Detection Tests for Group A Streptococcal Pharyngitis: Revisiting False-Positive Results Using Polymerase Chain Reaction Testing

Cohen, Jérémie F.; Cohen, Robert; Bidet, Philippe; Levy, Corinne; Deberdt, Patrice; d'Humières, Camille; Liguori, Sandrine; Corrard, François; Thollot, Franck; Mariani-Kurkdjian, Patricia; Chalumeau, Martin; Bingen, Edouard

Rapid-Antigen Detection Tests for Group A Streptococcal Pharyngitis: Revisiting False-Positive Results Using Polymerase Chain Reaction Testing

2013

We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.

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Palabras clave de AGROVOC

adolescent analysis antigens diagnosis genetics humans immunology methods microbiology pharyngitis pharyngitis pharynx polymerase chain reaction polymerase chain reaction staphylococcus aureus

Información bibliográfica

Publicado en

Journal of pediatrics

Volumen 162 Edición 6 Paginación 12821 - 12841 ISSN 0022-3476

Editorial

Mosby, Inc.

Otras materias

Sensitivity and specificity; Child; Preschool; Child; Case-control studies; Isolation & purification; False positive reactions; Bacterial; Streptococcal infections; Streptococcus pyogenes

Idioma

Inglés

Tipo

Text; Journal Article

En AGRIS desde: 2024-02-28

Formato: MODS

Proveedor de Datos

Este registro bibliográfico ha sido proporcionado por National Agricultural Library

Descubra la colección de este proveedor de datos en AGRIS

Enlaces

DOI http://dx.doi.org/10.1016/j.jpeds.2013.01.050

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