Rapid-Antigen Detection Tests for Group A Streptococcal Pharyngitis: Revisiting False-Positive Results Using Polymerase Chain Reaction Testing

Cohen, Jérémie F.; Cohen, Robert; Bidet, Philippe; Levy, Corinne; Deberdt, Patrice; d'Humières, Camille; Liguori, Sandrine; Corrard, François; Thollot, Franck; Mariani-Kurkdjian, Patricia; Chalumeau, Martin; Bingen, Edouard

Rapid-Antigen Detection Tests for Group A Streptococcal Pharyngitis: Revisiting False-Positive Results Using Polymerase Chain Reaction Testing

2013

We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.

Afficher plus [+]

Mots clés AGROVOC

adolescent analysis antigens diagnosis genetics humans immunology methods microbiology pharyngitis pharyngitis pharynx polymerase chain reaction polymerase chain reaction staphylococcus aureus

Informations bibliographiques

Publié dans

Journal of pediatrics

Volume 162 Numéro 6 Pagination 12821 - 12841 ISSN 0022-3476

Editeur

Mosby, Inc.

D'autres materias

Sensitivity and specificity; Child; Preschool; Child; Case-control studies; Isolation & purification; False positive reactions; Bacterial; Streptococcal infections; Streptococcus pyogenes

Langue

anglais

Type

Text; Journal Article

Sur AGRIS depuis: 2024-02-28

Format: MODS

Fournisseur de données

Cette notice bibliographique a été fournie par National Agricultural Library

Découvrez la collection de ce fournisseur de données dans AGRIS

Liens

DOI http://dx.doi.org/10.1016/j.jpeds.2013.01.050

Consulter Google Scholar