Rapid-Antigen Detection Tests for Group A Streptococcal Pharyngitis: Revisiting False-Positive Results Using Polymerase Chain Reaction Testing

Cohen, Jérémie F.; Cohen, Robert; Bidet, Philippe; Levy, Corinne; Deberdt, Patrice; d'Humières, Camille; Liguori, Sandrine; Corrard, François; Thollot, Franck; Mariani-Kurkdjian, Patricia; Chalumeau, Martin; Bingen, Edouard

Rapid-Antigen Detection Tests for Group A Streptococcal Pharyngitis: Revisiting False-Positive Results Using Polymerase Chain Reaction Testing

2013

We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.

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Ключевые слова АГРОВОК

adolescent analysis antigens diagnosis genetics humans immunology methods microbiology pharyngitis pharyngitis pharynx polymerase chain reaction polymerase chain reaction staphylococcus aureus

Библиографическая информация

Опубликовано в

Journal of pediatrics

Том 162 Выпуск 6 Нумерация страниц 12821 - 12841 ISSN 0022-3476

Издатель

Mosby, Inc.

Другие темы

Sensitivity and specificity; Child; Preschool; Child; Case-control studies; Isolation & purification; False positive reactions; Bacterial; Streptococcal infections; Streptococcus pyogenes

Язык

Английский

Тип

Text; Journal Article

В АГРИСе с: 2024-02-28

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

Откройте коллекцию этого поставщика данных в AGRIS

Ссылки

DOI http://dx.doi.org/10.1016/j.jpeds.2013.01.050

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