Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

Delaloye, Julie; De Bruin, Irma J.A.; Darling, Katharine E.A.; Reymond, Marlies Knaup; Sweep, Fred C.G.J.; Roger, Thierry; Calandra, Thierry; Cavassini, Matthias

Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

2012

Considering macrophage migratory inhibitory factor (MIF) as a critical pro-inflammatory cytokine of the immune system, we evaluated plasma MIF levels in 89 HIV-infected adults. Plasma MIF levels were higher in HIV-infected than in HIV-negative individuals. Highest MIF levels were observed during acute HIV infection (AHI) whilst patients on antiretroviral therapy (ART) had lower MIF levels, regardless of ART efficacy. Our results suggest that MIF is an integral component of the cytokine storm characteristic of AHI.

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AGROVOC Keywords

acute disease adults aged blood hiv infections hiv infections humans intramolecular oxidoreductases macrophages patients

Bibliographic information

Published in

Cytokine

Volume 60 Issue 2 Pagination 338 - 340 ISSN 1043-4666

Publisher

Elsevier Ltd

Other Subjects

Female; Middle aged; Migratory behavior; Adult; Macrophage migration inhibitory factors; Macrophage migration-inhibitory factors; Hiv seronegativity; Male; Therapeutics

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-29

Format: MODS

Data Provider

This bibliographic record has been provided by National Agricultural Library

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Links

DOI DOI http://dx.doi.org/10.1016/j.cyto.2012.07.027

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