Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

Delaloye, Julie; De Bruin, Irma J.A.; Darling, Katharine E.A.; Reymond, Marlies Knaup; Sweep, Fred C.G.J.; Roger, Thierry; Calandra, Thierry; Cavassini, Matthias

Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

2012

Considering macrophage migratory inhibitory factor (MIF) as a critical pro-inflammatory cytokine of the immune system, we evaluated plasma MIF levels in 89 HIV-infected adults. Plasma MIF levels were higher in HIV-infected than in HIV-negative individuals. Highest MIF levels were observed during acute HIV infection (AHI) whilst patients on antiretroviral therapy (ART) had lower MIF levels, regardless of ART efficacy. Our results suggest that MIF is an integral component of the cytokine storm characteristic of AHI.

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Mots clés AGROVOC

acute disease adults aged blood hiv infections hiv infections humans intramolecular oxidoreductases macrophages patients

Informations bibliographiques

Publié dans

Cytokine

Volume 60 Numéro 2 Pagination 338 - 340 ISSN 1043-4666

Editeur

Elsevier Ltd

D'autres materias

Female; Middle aged; Migratory behavior; Adult; Macrophage migration inhibitory factors; Macrophage migration-inhibitory factors; Hiv seronegativity; Male; Therapeutics

Langue

anglais

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-29

Format: MODS

Fournisseur de données

Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI DOI http://dx.doi.org/10.1016/j.cyto.2012.07.027

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