Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

Delaloye, Julie; De Bruin, Irma J.A.; Darling, Katharine E.A.; Reymond, Marlies Knaup; Sweep, Fred C.G.J.; Roger, Thierry; Calandra, Thierry; Cavassini, Matthias

Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

2012

Considering macrophage migratory inhibitory factor (MIF) as a critical pro-inflammatory cytokine of the immune system, we evaluated plasma MIF levels in 89 HIV-infected adults. Plasma MIF levels were higher in HIV-infected than in HIV-negative individuals. Highest MIF levels were observed during acute HIV infection (AHI) whilst patients on antiretroviral therapy (ART) had lower MIF levels, regardless of ART efficacy. Our results suggest that MIF is an integral component of the cytokine storm characteristic of AHI.

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Palabras clave de AGROVOC

acute disease adults aged blood hiv infections hiv infections humans intramolecular oxidoreductases macrophages patients

Información bibliográfica

Publicado en

Cytokine

Volumen 60 Edición 2 Paginación 338 - 340 ISSN 1043-4666

Editorial

Elsevier Ltd

Otras materias

Female; Middle aged; Migratory behavior; Adult; Macrophage migration inhibitory factors; Macrophage migration-inhibitory factors; Hiv seronegativity; Male; Therapeutics

Idioma

Inglés

Tipo

Journal Article; Text

En AGRIS desde: 2024-02-29

Formato: MODS

Proveedor de Datos

Este registro bibliográfico ha sido proporcionado por National Agricultural Library

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Enlaces

DOI DOI http://dx.doi.org/10.1016/j.cyto.2012.07.027

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