Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

Delaloye, Julie; De Bruin, Irma J.A.; Darling, Katharine E.A.; Reymond, Marlies Knaup; Sweep, Fred C.G.J.; Roger, Thierry; Calandra, Thierry; Cavassini, Matthias

Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

2012

Considering macrophage migratory inhibitory factor (MIF) as a critical pro-inflammatory cytokine of the immune system, we evaluated plasma MIF levels in 89 HIV-infected adults. Plasma MIF levels were higher in HIV-infected than in HIV-negative individuals. Highest MIF levels were observed during acute HIV infection (AHI) whilst patients on antiretroviral therapy (ART) had lower MIF levels, regardless of ART efficacy. Our results suggest that MIF is an integral component of the cytokine storm characteristic of AHI.

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Ключевые слова АГРОВОК

acute disease adults aged blood hiv infections hiv infections humans intramolecular oxidoreductases macrophages patients

Библиографическая информация

Опубликовано в

Cytokine

Том 60 Выпуск 2 Нумерация страниц 338 - 340 ISSN 1043-4666

Издатель

Elsevier Ltd

Другие темы

Female; Middle aged; Migratory behavior; Adult; Macrophage migration inhibitory factors; Macrophage migration-inhibitory factors; Hiv seronegativity; Male; Therapeutics

Язык

Английский

Тип

Journal Article; Text

В АГРИСе с: 2024-02-29

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

Откройте коллекцию этого поставщика данных в AGRIS

Ссылки

DOI DOI http://dx.doi.org/10.1016/j.cyto.2012.07.027

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