Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?

Doppler, Wolfgang; Jansen‐Dürr, Pidder

Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?

2019

Doppler, Wolfgang | Jansen‐Dürr, Pidder

Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by matrix metalloproteases. Increased production of mitochondrial reactive oxygen species (mtROS) via NADPH oxidase 4 (NOX4) is implicated in this process. Hydrogen peroxide‐inducible clone‐5 (HIC‐5) is postulated to sense both matrix detachment of transformed cells and intracellular ROS and can inhibit ras signaling via inhibition of NOX4.

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Mots clés AGROVOC

hydrogen mitochondria neoplasms reactive oxygen species

Informations bibliographiques

Publié dans

FEBS journal

Volume 286 Numéro 3 Pagination 456 - 458 ISSN 1742-464X

Editeur

Entomological Society of America

D'autres materias

Metalloproteinases; Oncogenes; Nadp (coenzyme); Metastasis; Nad(p)h oxidase (h2o2-forming)

Langue

anglais

Note

Journal article

Licence

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Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

Format: MODS

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Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI http://dx.doi.org/10.1111/febs.14746

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