Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?

Doppler, Wolfgang; Jansen‐Dürr, Pidder

Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?

2019

Doppler, Wolfgang | Jansen‐Dürr, Pidder

Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by matrix metalloproteases. Increased production of mitochondrial reactive oxygen species (mtROS) via NADPH oxidase 4 (NOX4) is implicated in this process. Hydrogen peroxide‐inducible clone‐5 (HIC‐5) is postulated to sense both matrix detachment of transformed cells and intracellular ROS and can inhibit ras signaling via inhibition of NOX4.

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Ключевые слова АГРОВОК

hydrogen mitochondria neoplasms reactive oxygen species

Библиографическая информация

Опубликовано в

FEBS journal

Том 286 Выпуск 3 Нумерация страниц 456 - 458 ISSN 1742-464X

Издатель

Entomological Society of America

Другие темы

Metalloproteinases; Oncogenes; Nadp (coenzyme); Metastasis; Nad(p)h oxidase (h2o2-forming)

Язык

Английский

Примечание

Journal article

Лицензия

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Тип

Journal Article; Text

В АГРИСе с: 2024-02-28

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

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Ссылки

DOI http://dx.doi.org/10.1111/febs.14746

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