Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?
2019
Doppler, Wolfgang | Jansen‐Dürr, Pidder
Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by matrix metalloproteases. Increased production of mitochondrial reactive oxygen species (mtROS) via NADPH oxidase 4 (NOX4) is implicated in this process. Hydrogen peroxide‐inducible clone‐5 (HIC‐5) is postulated to sense both matrix detachment of transformed cells and intracellular ROS and can inhibit ras signaling via inhibition of NOX4.
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书目信息
FEBS journal
卷
286
期
3
页码
456
- 458
ISSN
1742-464X
出版者
Entomological Society of America
其它主题
Metalloproteinases; Oncogenes; Nadp (coenzyme); Metastasis; Nad(p)h oxidase (h2o2-forming)
语言
英语
注释
Journal article
许可
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类型
Journal Article; Text
2024-02-28
MODS
