Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?

Doppler, Wolfgang; Jansen‐Dürr, Pidder

Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?

2019

Doppler, Wolfgang | Jansen‐Dürr, Pidder

Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by matrix metalloproteases. Increased production of mitochondrial reactive oxygen species (mtROS) via NADPH oxidase 4 (NOX4) is implicated in this process. Hydrogen peroxide‐inducible clone‐5 (HIC‐5) is postulated to sense both matrix detachment of transformed cells and intracellular ROS and can inhibit ras signaling via inhibition of NOX4.

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Palabras clave de AGROVOC

hydrogen mitochondria neoplasms reactive oxygen species

Información bibliográfica

Publicado en

FEBS journal

Volumen 286 Edición 3 Paginación 456 - 458 ISSN 1742-464X

Editorial

Entomological Society of America

Otras materias

Metalloproteinases; Oncogenes; Nadp (coenzyme); Metastasis; Nad(p)h oxidase (h2o2-forming)

Idioma

Inglés

Nota

Journal article

Licencia

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Tipo

Journal Article; Text

En AGRIS desde: 2024-02-28

Formato: MODS

Proveedor de Datos

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Enlaces

DOI http://dx.doi.org/10.1111/febs.14746

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